Programmed Cell Death and Myocardial Ischemia Reperfusion Injury

Acute myocardial infarction has a rapid onset, is severe and high mortality rate that seriously threatens the lives of population. Coronary intervention combined with drug treatment can open criminal blood vessel save patient's life, but surviving patient not "cured" must go through process ischemia reperfusion injury. Myocardial cells are end-stage death due to injury irreversibly damages structure function heart. In past, apoptosis was thought be only regulated form cell death, whereas necrosis not. However, recent studies suggest also regulated, which grouped under term programmed death. Since actively mediated by molecular signaling pathways, there possibility inhibit this thus attenuate Currently, mainly includes apoptosis, autophagy, pyroptosis, necroptosis, ferroptosis. paper, we explore relationship between ischemic injury, in order support prevention intervening perspective